Özgeçmiş - Yrd. Doç. Dr. Necla BIRGÜL-IYISON


Dr. Öğr. Üyesi Necla Birgül Iyison
Boğaziçi University
Molecular Biology and Genetics
Kuzey Park, 313
34342 Bebek/Istanbul
Turkey
+90 (212) 359 7284
birgul@boun.edu.tr
  Dr. Necla Birgül Iyison'in özgeçmişini indir
                (en son düzenleme tarihi: 29.07.2022)


Eğitim

Başlangıç Tarihi Mezuniyet Tarihi Üniversite Bölüm (Program)
PhD Eylül 1997 Ocak 2001 Hamburg Üniversitesi Institut für Zellbiochemie und klinische Neurobiologie, Hamburg
MSc Eylül 1994 Eylül 1997 Hamburg Üniversitesi Institut für Allgemeine Botanik
BSc Eylül 1989 Eylül 1993 Trakya Üniversitesi Fen Fakültesi

Akademik Unvanlar ve Kadrolar

Boğaziçi Üniversitesi’nde ilk atanma tarihi: Ocak 2002
Boğaziçi Üniversitesi’nde ilk atandığı kadro: Öğretim Görevlisi
Boğaziçi Üniversitesi’nde Dr. Öğretim Üyeliğine ilk atanma tarihi : 2004
Üniversitelerarası Kurul Doçentlik ünvan tarihi: -
Boğaziçi Üniversitesi’nde Doçentlik kadrosuna atanma tarihi: -

İş Deneyimi (BÜ dişindaki)

İşveren Görevin Adı Görev alma tarihleri
Hamburg Üniversitesi Doktora sonrası 2001 (3 ay)
Cape Town Üniversitesi Doktora sonrası 2001 (9 ay)

Araştırma Konuları

  • Sinyal İletim
  • G-ProteinKenetli Reseptörler (GPCRs)
  • İlaç Tasarımı
  • Moleküler Dinamik ve Simülasyon

Araştırma Projeleri

Fonlayan kuruluş Proje başlığı Projedeki görev Tarihleri
Institution Title Role Dates

Yayın Sayıları (overview)

Uluslararası hakemli dergilerde yayımlanan makaleler
Index Makaleler
(Doktora'dan)
Makaleler
(Doktora dişindaki'dan)
Makaleler
(BU lisansüstu tezler'den)
SCI-E/SSCI/AHCI 2 18 14
ESCI - - -
Scopus - - -
Diğer - - -
Kitaplar
Kitaplar Uluslararası: -
Ulusal: -
Kitap bölümleri Uluslararası: 1
Ulusal: -
Kitap editörlükleri Uluslararası: -
Ulusal: -

Atıflar

Web of Science Google Scholar
h-endeksi: 8 8
Kendine atıflar hariç atıf sayısı: 352
Toplam atıf sayısı: 371 526

Patentler

Patent sahipl(ler)i Patent başliği Patent numarasi Başvuru tarihi Yayın yılı Patent ofisi
- - - - - -

Yönetilen Tez Sayısı

Yükesek Lisans Doktora Kurum
Completed: - - -
Ongoing: - - -

Ödüller

Award Title Awarding Institution Award Year
- - -

Yayın Listesi

Uluslararası hakemli dergilerde yayımlanan makaleler

  • Ferdows Afghah, Necla Birgul Iyison, Ali Nadernezhad, Ahmet Midi, Ozlem Sen, Burcu Saner Okan, Mustafa Culha, and Bahattin Koc:“ 3D Fiber Reinforced Hydrogel Scaffolds by Melt Electrowriting and Gel Casting as a Hybrid Design for Wound Healing“ Advanced Healthcare Materials, 2022, 2102068, doi: 10.1002/adhm.202102068 Q1, IF: 11.92, SCIE

  • Serdar Durdagi, Muge Didem Orhan, Busecan Aksoydan, Seyma Calis, Berna Dogan, Kader Sahin, Aida Shahraki, Necla Birgül Iyison, and Timucin Avsar: „Screening of Clinically Approved and Investigation Drugs as Potential Inhibitors of SARS-CoV-2: A Combined in silico and in vitro Study“ Molecular Informatics, 2021 doi.org/10.1002/minf.202100062 Q1, IF: 4.05, SCIE

  • Aslan T, Yenenler-Kutlu A, Gerlevik U, Aktugülu Zeybek Ac, Kiykim E, Sezerman OU, Birgul Iyison N: "Identifying and elucidating the roles of Y198N and Y204F mutations in the PAH enzyme through molecular dynamic simulations." J Biomol Struct Dyn. 2021 May 10:1-12. doi: 10.1080/07391102.2021.1921619 Q1, IF: 4.15, SCIE

  • Shahraki, A., Isbilir, A., Dogan, B., Lohse, M.J., Durdagi, S., Birgul Iyison, N: "Structural and Functional Characterization of Allatostatin Receptor Type-C of Thaumetopoea pityocampa, a Potential Target for Next-Generation Pest Control Agents". J Chem Inf Model. 2021 Jan 21. doi: 10.1021/acs.jcim.0c00985 Q1, IF: 4.95, SCIE

  • Birgul Iyison, N., Shahraki, A., Kahveci, K., Duzgun, M.B., Gun, G: "Are Insect GPCRs Ideal Next-Generation Pesticides: Opportunities and Challenges". FEBS J. 2021 Jan 8. doi: 10.1111/febs.15708. Q1, IF: 5.54, SCIE

  • Birgul Iyison, N., Devlet Kilickap, B., Duan Sahbaz, B., Vardar, B., Guclu, B: "Distribution and mRNA expression of nAChRs in the rat S1 and M1 cortices after electrical stimulation of the basal forebrain". Turkish Neurosurgery, 2021 Jan 07. doi: 10.5137/1019-5149.JTN.31865-20.3 Q3, IF: 1.04, SCIE

  • Isbilir, A., Duan Sahbaz, B., Tuncgenc, G., Bünemann, M., Lohse, M.J., Birgul-Iyison, N:"Pharmacological Characterization of the Stick Insect Carausius morosus Allatostatin C Receptor with Its Endogenous Agonist". ACS Omega, 2020 Dec. DOI.10.1021/acsomega.0c03382 Q1, IF: 4.13, SCIE

  • Necla Birgul Iyison, Merve Gizem Sinmaz, Burcin Duan Sahbaz, Aida Shahraki, Busecan Aksoydan, Serdar Durdagi:“In silico characterization of adipokinetic hormone receptor and screening for pesticide candidates against stick insect, Carausius morosus“, Journal of Molecular Graphics and Modelling (2020) 107720, DOI.org/10.1016/j.jmgm.2020.107720 Q1, IF: 2.51, SCIE

  • Aida Shahraki, Yanying Yu, Zeynep Melis Gul, Chunguang Liang, Necla Birgul Iyison: “Whole Genome Sequencing of Thametopoea pityocampa Revealed Putative Pesticide Targets”, Genomics 112 (2020) 4203–4207, DOI.org/10.1016/j.ygeno.2020.07.017 Q1, IF: 5.73, SCIE

  • Akiva I. and N. Birgül Iyison: MGAT1 is a novel transcriptional target of Wnt/β catenin signaling pathway BMC Cancer 18:60 DOI.org/10.1186/s12885-017-3960-7, 2018 Q1, IF: 4.63, SCIE

  • Burcin Duan Sahbaz, Osman Ugur Sezerman, Hamdi Torun & Necla Birgül Iyison: Ligand binding pocket of a novel Allatostatin receptor type C of stick insect, Carausius morosus. Scientific Reports, 7:41266, DOI: 10.1038/srep41266, 2017, Q1, IF: 4.37, SCIE

  • Ayaz Najafov, Tuncay Şeker, İpek Even, Gerta Hoxhaj, Osman Selvi, Duygu Esen Özel, Ahmet Koman and Necla Birgül-İyison: Wnt/beta-Catenin pathway regulates transcription of actin-regulatory protein MENA, PLoS ONE, Volume 7, Issue 5, e37013, DOI:10.1371/journal.pone.0037013, 2012, Q , IF: 3.24, SCIE

  • Kavak E., Najafov A., Ozturk N., Seker T., Cavusoglu K., Aslan T., Duru A.D., Saygili T., Hoxhaj G., Hiz M.C., Ozer-Unal D., Birgul-Iyison N., Ozturk M., Koman A. „Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets“.Cellular Signalling, Vol. 22, pp. Q1, IF: 4.31, SCIE

  • Kreienkamp HJ, Larusson HJ, Witte I, Roeder T, Birgul N, Honck HH, Harder S, Ellinghausen G, Buck F, Richter D. “Functional annotation of two orphan G-protein-coupled receptors, Drostar1 and -2, from Drosophila melanogaster and their ligands by reverse pharmacology”. J Biol Chem. 2002 Oct 18;277(42):39937-43. Epub 2002 Aug 6. DOI:10.1074/jbc.M206931200 Q1, IF: 5.15, SCIE

  • Auerswald L, Birgul N, Gade G, Kreienkamp HJ, Richter D. “Structural, functional, and evolutionary characterization of novel members of the allatostatin receptor family from insects”. Biochem Biophys Res Commun. 2001 Apr13;282(4):904-9. DOI:10.1006/bbrc.2001.4659 Q1, IF: 3.19, SCIE

  • Birgul N, Weise C, Kreienkamp HJ, Richter D.“Reverse physiology in drosophila: identification of a novel allatostatin-like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin/galanin/opioid receptor family”. EMBOJ:18(21):5892–5900. DOI:10.1093/emboj/18.21.5892,1999 Q1, IF: 11.59, SCIE

Uluslararası kitaplar, kitap bölümleri ve kitap editörlükleri

  • Duan Sahbaz B., Birgül Iyison N. “Ligands” Chapter: Neuropeptides as Ligands of GPCRs; In Tech Open Science, 2018

Ulusal hakemli dergilerde yayımlanan makaleler

  • Duan Sahbaz, B., Birgül İyison, N: Prediction and expression analysis of G protein-coupled receptors in the laboratory stick insect, Carausius morosus. Turkish Journal of Biology, 43, 77-88, DOI.10.3906/biy-1809-27, 2019, Q2, IF: 3.47, SCIE

  • İzzet Akiva, Necla Birgül Iyison:“Identification of IFITM3 and MGAT1 as novel interaction partners of BRI3 by Yeast Two-Hybrid Screening“, Turkish Journal of Biology, DOI.10.3906/biy-1805-47, 2018, Q2, IF: 3.47, SCIE

  • İ. Even, İ. AKİVA, N. Birgül Iyison:“In vivo RNAi mini-screen in Drosophila cancer model reveals novel potential Wnt targets in liver cancer“, Turkish Journal of Gastroenterology, DOI.10.5152/tjg.18241, 2018, Q3, IF: 1.55, SCIE

  • Isler C., Tanriverdi T , Kavak E., Sanus G.Z., Ulu M.O., Erkanlı G., Koman A., Birgül-Iyison N., Uzan M. “Prenatal Expressions of Hyperpolarization Cyclic-Nucleotide-Gated Channel (HCN) Genes in Dysplastic Hippocampi in Rats”, Türkish Neurosurgery 2008, Vol:18, No.4, 327-335. (PMID:19107678), Q3, IF: 1.03, SCIE

Ukusal kitaplar, kitap bölümleri ve kitap editörlükleri

  • -

Yönetilen Tezlerin Listesi

Devam eden
  • Gökhan Gün:”Investigation of the mechanism of Cry toxins in Asian Mosquito”

  • Alize Yılmazlar: “Characterisation and functional analysis of the orphan G-protein coupled receptor GPR141”

  • Barbaros Düzgün: “Structural and functional analysis of the orphan G-protein coupled receptor GPR160”

  • Muhammed Fatih Karakaya: “Functional analysis of the orphan G-protein coupled receptor GPR25”

  • Kübra Kahveci: “Functional analysis of the allosteric pocket of Allatostatin receptor in T. pit”

Tamamlanan
  • Erşen Kavak: “Defining novel cancer genes, sage tags and co-regulated regions of the human genome evolving from the search and identification of novel Wnt/Tcf/beta-Catenin (PhD) targets”, 2009 (Co-advised)

  • Tuncay Şeker: “Proteomics based search for novel SIK2 substrates involved in Endoplasmic Reticulum homeostasis”, 2016 (PhD)

  • İzzet Akiva: “Characterization of novel Wnt/beta Catenin pathway targets”, 2016 (PhD)

  • Burçin Duan Şahbaz: “Neuropeptidome and GPCRome of Stick Insect: Specific structural and functional aspects of Allatostatin receptor”, 2017 (PhD)

  • Aida Shahraki: “Functional and Structural into novel insect G- protein coupled receptor Allatostatin Type C receptor of Pine processionary moth”, 2020 (PhD)

  • Tolga Aslan: “Characterization of GPR139 and investigating its possible role in brain development”, 2022 (PhD)

  • "Ayaz Najafov: Mena, Bri3 and Hsf2 as novel transcriptional targets of the Wnt/Beta-Catenin pathway; 2008
    Wnt/Beta-Catenin pathway; 2008 (MSc)"

  • Tolga Aslan: Verification of putative novel Wnt/Beta-Catenin pathway targets using alternative effectors; 2009 (MSc)

  • Tuncay Şeker: Characterization of C17ORF45 as a novel target of Wnt/Beta- Catenin pathway; 2009 (MSc)

  • Izzet Akiva: Identification of novel proteins that interact with BRI3, a putative transcriptional target of the wnt/beta-Catenin signaling pathway; 2009 (MSc)

  • Emine Dindar: Identification of protein partners of acidic calponin; 2010 (MSc)

  • Ipek Even: Identification and in vivo analysis of putative Wnt target genes with effective roles in cancer; 2012 (MSc)

  • Burçin Duan: Identification and docking analysis of Allatostatin receptor in Carausisu morosus; 2012 (MSc)

  • Vahap Kapıkıran: C17ORF45 gene, does it or does it not translate a protein; 2012 (MSc)

  • Esra Şekerci: How are foxo-transcription factors regulated after lithium induced cell cycle arrest in hepatocellular carcinoma cells; 2013 (MSc)

  • Ruçhan Karaman: Mammalian enabled (Mena): a possible regulator of YAP oncoprotein; 2014 (MSc)

  • Ali İşbilir: Pharmacological characterization of PICF-Allatostatin receptor in Carausius morosus; 2016 (MSc)

  • Merve Gizem Sınmaz: Characterization of Adipokinetik hormone receptor in stick insect, Carausius morosus; 2018 (MSc)

  • Ayşe Nur Kayabaşı: Verification of novel Wnt/beta-Catenin Target, 2019 (MSc)

Konferans Sunuları

Son Üç Yıldakı Konferans Sunuları
  • Burçin Duan Şahbaz ve Necla Birgül Iyison: Yeni Bir Allatostatin ReseptörününTanımlanması ve Ligand Bağlanma Cebinin Bulunması, 24. Ulusal Biyoloji Kongresi, Celal Bayer University Manisa/Izmir (10-14.09.2018)

  • Tolga Aslan ve Necla Birgül Iyison: Yeni bir PAH Varyantının Moleküler Modellemesi ve Moleküler Dinamik Simülasyonu, Erciyes Tıp Günleri Kayseri (7-10.03.2018)

  • İzzet Akiva ve Necla Birgül: “BRI3 is a novel Wnt/beta Catenin target” 1st International Multidisciplinary Cancer Research Congress” 18-22 September 2019, Diyarbakır

  • İzzet Akiva ve Necla Birgül: “BRI3 is a novel Wnt/beta Catenin target” 7th International Congress of the Molecular Biology Association of Turkey; 27-29 September 2019 Istanbul

  • Necla Birgul-Iyison: „Allatostatin receptor, potential target for next- generation pesticides“ 5th General ERNEST Meeting: Bridging Perspectives and Networking in Signal Transduction Research, Bari/Italy 4-6 October 2021

  • Kubra Kahveci, Serdar Durdaği, Necla Birgül: “Targeting Allatostatin Type-C receptor of Thaumetopoea pityocampa for novel agonists as next-generation pesticide” Agricultural, Biological & Life Sciences Conference 29-31 August 2022 Edirne, Turkey

Idari Görevleri

Kurum Fakülte / Bölüm Görev Tarihler
Boğaziçi Universitesi FEF/MBG Bölüm Başkan Yardımcısı - MBG Department 2013 - 2017
Boğaziçi Universitesi BÜ Rektörlük Vivarium Koordinatörü 2015- devam etmekte
Boğaziçi Universitesi BÜ Rektörlük Kurumsal Hayvan Deneyleri Yerel Etik Kurulu üye 2017- devam etmekte
Istanbul Teknik Üniversitesi İTÜ Rektörlük Kurumsal Hayvan Deneyleri Yerel Etik Kurulu 2021- devam etmekte

Son Beş Yılda Verilen Dersler

Ders Kodu Ders Adı Dönem Fakülte yüzdelik sıra
Bio308 Seminar I 2021/2022-1 88.67
Bio48F Drug Design 2021/2022-1 70.44
Bio491 Special Project II 2021/2022-1 n.d
Bio308 Seminar I 2021/2022-2 n.d
Bio493 Signaling and Cancer 2021/2022-2 67.95
Bio492 Special Project II 2021/2022-2 n.d
Bio308 Seminar I 2020/2021-1 n.d
Bio407 Seminar II 2020/2021-1 n.d
Bio493 Signaling and Cancer 2020/2021-1 45.02
Bio 58F Drug Design 2020/2021-1 n.d
Bio308 Seminar I 2020/2021-1 n.d
Bio48F Drug Design 2019/2020-2 n.d
Bio492 Special Project II 2019/2020-2 n.d
Bio407 Seminar II 2019/2020-2 52.6
Bio355 Molecular Biology Lab. 2019/2020-I n.d
Bio 58F Drug Design 2019/2020-1 82.35
Bio152 Introduction to modern Biology 2019/2018-2 n.d
Bio308 Seminar I 2019/2018-2 n.d
Bio492 Special Project II 2019/2018-2 n.d
Bio101 Cellular and Molecular Biology 2019/2018-1 n.d
Bio355 Molecular Biology Lab. 2019/2018-1 10.08 (Shared with TA’s)
Bio407 Seminar II 2019/2020-2 n.d
Bio491 Special Project I 2019/2018-1 n.d
Bio492 Special Project II 2017/2018-2 n.d
Bio308 Seminar I 2017/2018-2 n.d
Bio410 Cancer Biology 2017/2018-2 n.d
Bio111 Prelude to Molecular Biology 2017/2018-1 39.56 (Staff)
Bio355 Molecular Biology Lab. 2017/2018-1 28.16
Bio407 Seminar II 2017/2018-1 n.d
Bio407 Seminar II 2017/2018-1 n.d



en son düzenleme tarhihi: 11/25/22