Resume - Assoc. Prof. Dr. Umut Şahin


Asst. Prof. Dr. Umut Şahin
Boğaziçi University
Molecular Biology and Genetics
Kuzey Park, 312
34342 Bebek/Istanbul
Turkey
+90 (212) 359 7383
umut.sahin@boun.edu.tr 		  download Dr. Umut Şahin's CV
                (last updated: 22.11.2022)


Education

Start date Graduation date University Department (Program)
PhD September 1999 May-05 Brown University Molecular and cellular biology and biochemistry
MSc - - - -
BSc September 1995 June 1999 Boğaziçi University Molecular biology and genetics

Academic Titles and Positions

Initial appointment at Boğaziçi University: November 2015
First academic position at Boğaziçi University: Assistant Professor
Date of appointment as Assistant Professor at Boğaziçi University: November 2015
Date Associate Professorship was granted by YÖK: November 2017
Date of promotion to Associate Professor at Boğaziçi University: October 2018

Experiences / Appointments (outside BU)

Employer Job Title Employment dates
INSERM, CNRS (Paris, Fransa) Postdoc 2010-2015
Institut Pasteur (Paris, Fransa) Postdoc 2007-2010
Weill Medical College of Cornell University Postdoc 2005-2007
Memorial Sloan-Kettering Cancer Center PhD student 2001-2005

Research Interests

  • Protein biochemistry, post-translational protein modifications, SUMO/Ubiquitin, degradation
  • Targeted therapy, neurodegeneration
  • Cell biology

Research Projects

Funding Institution Project Title Role Dates
Tübitak 2247 National Research Leaders Programme Investigation of the relationship between ectodomain shedding and SUMO modification Principle Investigator 2022-2025
Tübitak / Fransa Bilateral Bosphorus Project Support Investigation of the relationship between sumoylation and ALS pathogenesis Principle Investigator 2020-2022
Gilead, Inc. Investigation of the relationship between HIV1 and cellular sumoylation Principle Investigator 2016-2017-2019
EMBO (European Molecular Biology Organization) Installation Grant A novel therapeutic strategy to combat disease: PML nuclear bodies enforce protein hyper-sumoylation, ubiquitination and degradation. Implications for Amyotrophic Lateral Sclerosis pathogenesis and treatment. Principle Investigator 2016-2021
Fondation Recherche Medicale Investigation of the theraputic mechanism of a combination therapy for Adult T-cell lymphoma Researcher 2010-2012

Publications (overview)

Publications in refereed international journals
Index Publications
(from PhD)		 Publications
(outside PhD)		 Publications
(from BU Graduate Theses)
SCI-E/SSCI/AHCI 4 10 4
ESCI
Scopus
Other indexes
Books
Books International Publishers: -
National Publishers: -
Book chapters International Publishers: -
National Publishers: -
Edited Books International Publishers: -
National Publishers: -

Citations

Web of Science Google Scholar
h-index: 12 13
Number of citations w/o self citation: 1458
Total number of citations: 1487 2222

Patents

Patent owner Title Number Application date Publication year Patent office
- - - - - -

Theses Supervised

MSc PhD Institution
Completed: - - -
Ongoing: - - -

Awards

Award Title Awarding Institution Award Year
Science Academy Young Investigator Programme Science Academy Turkey 2016
Gilead Turkey Award Gilead Inc 2016, 2017, 2019
EMBO Installation Grant European Molecular Biology Organization 2016

Publications

Publications in refereed international journals

  • Sahin U (2022) Umut Şahin : Sumoylation in health and disease. Life Sci Alliance. 5(6). IF: 5.78, Q1
  • Sahin U, de Thé H, Lallemand-Breitenbach V (2022) Sumoylation in Physiology, Pathology and Therapy. Cells 11(5) : 814 IF: 7.66, Q1
  • Mete B, Pekbilir E, Bilge BN, Georgiadou P, Celik E, Sutlu T, Tabak F, Sahin U (2022) Human Immınodeficiency Virus Type 1 Impairs Sumoylation. Life Sci Alliance. 5(6). IF: 5.78, Q1
  • Ergünay T, Ayhan Ö, Celen AB, Georgiadou P, Pekbilir E, Abaci YT, Yesildag D, Rettel M, Sobhiafshar U, Ogmen A, Emre NCT, Sahin U (2022) Sumoylatin of Cas9 at Lysine 848 Regulates Protein Stability and DNA Binding. Life Sci Alliance. 5(4). IF: 5.78, Q1
  • Celen AB and Sahin U (2020) Sumoylation on its 25th anniversary : mechanisms, pathology, and emerging concepts. FEBS J. 287(15):3110-3140. doi: 10.1111/febs.15319. IF: 5.62, Q1
  • Auvin S, Öztürk H, Abaci YT, Mautino G, Meyer-Losic F, Jollivet F, Bashir T, de Thé H, Sahin U (2019) A molecule inducing androgen receptor degradation and selectively targeting prostate cancer cells. Life Sci Alliance. 2(4):e201800213. doi: 10.26508/lsa.201800213. IF: 5.78, Q1
  • Maretzky T, Swendeman S, Mogollon E, Weskamp G, Sahin U, Reiss K, Blobel CP (2017) Characterization of the catalytic properties of the membrane-anchored metalloprotease ADAM9 in cell-based assays. Biochem J. 474(9) : 1467-147 IF: 4.09, Q1
  • Sahin U#, Jollivet F, Berthier C, de Thé H, Lallemand-Breitenbach V (2016) Detection of protein sumoylation in situ by proximity ligation assays. Methods Mol Biol. 1475 :139-150 IF: 1.37, Q1
    (# corresponding author)
  • El Hajj H, Dassouki Z, Berthier C, Raffoux E, Ades L, Legrand O, Sahin U, Tawil N, Salameh A, Zibara K, Darwiche N, Mohty M, Dombret H, Fenaux P, de Thé H, Bazarbachi (2015) Retinoic acid and arsenic trioxide degrade mutated NPM-1 initiating apoptosis of AML cells. Blood. 125(22) :3447-54 IF: 25.4, Q1
  • Dassouki Z*, Sahin U*#, El Hajj H, Jollivet F, Kfoury Y, Lallemand-Breitenbach V, Hermine O, Bazarbachi A, de Thé H (2015) Adult T-cell Lymphoma Response to Arsenic/Interferon Therapy is Triggered by SUMO/PML/RNF4-dependent Tax Degradation. Blood. 125(3) :474-82 (*co-first authors, # corresponding author) IF: 25.4, Q1
  • Sahin U, de Thé H, Lallemand-Breitenbach V (2014) PML Nuclear Bodies : Assembly and Oxidative Stress-sensitive Sumoylation. Nucleus. 5(6) : 499-507 IF: 3.45, Q1
  • Sahin U, Lallemand-Breitenbach V, de Thé H (2014) PML Nuclear Bodies : Regulation, Function and Therapeutic Perspectives. J Pathol. 234(3) : 289-91 IF: 7.99, Q1
  • Sahin U#, Lapaquette P, Andrieux A, Faure G, Dejean A (2014) Sumoylation of Human Argonaute-2 at Lysine 402 Regulates its Stability. PLoS One. 9(7) : e102957 doi : 10.1371/journal.pone.0102957 (# corresponding author) IF: 3.75, Q1
  • Sahin U, Ferhi O, Carnec X, Zamborlini A, Peres L, Jollivet F, Vitaliano-Prunier A, de Thé H, Lallemand-Breitenbach V (2014) Interferon Controls SUMO Availability via the Lin28 and let-7 Axis to Impede Virus Replication. Nat Commun. 5 : 4187 doi : 10.1038/ncomms5187 IF: 17.7, Q1
  • Sahin U, Ferhi O, Jeanne M, Benhenda S, Berthier C, Jollivet F, Niwa-Kawakita M, Faklaris O, Setterblad N, de Thé H, Lallemand-Breitenbach V (2014) Oxidative Stress-induced Assembly of PML Nuclear Bodies Controls Sumoylation of Partner Proteins. J Cell Biol. 204(6) : 931-45 IF: 10.5, Q1
  • Sahin U, Blobel CP (2007) Ectodomain Shedding of the EGF-receptor Ligand Epigen is Mediated by ADAM17. FEBS Lett. 581(1) : 41-4 IF: 4.12, Q1
  • Sahin U, Weskamp G, Zheng Y, Chesneau V, Horiuchi K, Blobel CP (2006) A Sensitive Method to Monitor Ectodomain Shedding of Ligands of the Epidermal Growth Factor Receptor. Methods Mol Biol. 327 : 99-113 IF: 1.37, Q1
  • Sahin U, Weskamp G, Kelly K, Zhou HM, Higashiyama S, Peschon J, Hartmann D, Saftig P, Blobel CP (2004) Distinct Roles for ADAM10 and ADAM17 in Ectodomain Shedding of Six EGFR Ligands. J Cell Biol. 164(5) : 769-79 IF: 10.5, Q1
  • Zhou HM, Weskamp G, Chesneau V, Sahin U, Vortkamp A, Horiuchi K, Chiusaroli R, Hahn R, Wilkes D, Fisher P, Baron R, Manova K, Basson CT, Hempstead B, Blobel CP (2004) Essential Role for ADAM19 in Cardiovascular Morphogenesis. Mol Cell Biol. 24(1) : 96-104 IF: 4.27, Q1

Books, Book chapters, and Editorschips for international publishers

  • -

Publications in refereed national journals

  • -

Books, Book chapters, and Editorschips for national publishers

  • -

Supervised Theses

Ongoing
  • -

Completed
  • Identification of the major sumoylation site on crispr cas9 protein (Duygu Yeşildağ, BÜ Yüksek Lisans Öğrencisi) (2019)
  • A novel posttranslational modification on the central CRISPR enzyme: discovery of Cas9 ubiquitylatin (Arda Baran Çelen, BÜ Yüksek Lisans Öğrencisi) (2019)
  • Investigation of the pathogenic basis of NEK1-linked amyotrophic lateral sclerosis and discovery of a potential treatment that prevents protein aggregation through targeted destruction (Harun Öztürk, BÜ Yüksek Lisans Öğrencisi) (2019)
  • The assessment of ubiquitin E3 ligase activity of RNF4 on ALS-related NEK1 protein (Sezgi Canaslan, BÜ Yüksek Lisans Öğrencisi) (2019)
  • Investigation of the effects of SUMO modification on two critical proteins: a pathogenic NEK1 mutant that drives ALS pathogenesis and the CRISPR-associated Cas9 protein (Tunahan Ergünay, BÜ Yüksek Lisans Öğrencisi) (2022)
  • Investigation of the impact of Human Immunodeficiency Virus on cellular sumoylation (Emre Pekbilir, BÜ Yüksel Lisans Öğrencisi, 2022)

Conference Presentations

Conference contributions of the past 3 years
  • -

Administrative Positions

Institution Faculty / Department Position Dates
Boğaziçi University Department of Molecular Biology and Genetics Department Vice Chair April 2020-2023
Boğaziçi University Research Policies Council Member 2018-

Courses of the past 5 years

Code Name Term Faculty Percentile Rank
Bio302 Biochemistry 2 2022 Spring
Bio308 Seminar 1 2022 Spring
Bio492 Special Projects 2 2022 Spring
Bio331 Techniques in Biological Research 2021 Fall
Bio333 Biochemistry Laboratory 2021 Fall
Bio491 Special Projects 1 2021 Fall
Bio302 Biochemistry 2 2021 Spring
Bio308 Seminar 1 2021 Spring
Bio492 Special Projects 2 2021 Spring
Bio331 Techniques in Biological Research 2020 Fall
Bio333 Biochemistry Laboratory 2020 Fall
Bio491 Special Projects 1 2020 Fall
Bio302 Biochemistry 2 2020 Spring
Bio492 Special Projects 2 2020 Spring
Bio331 Techniques in Biological Research 2019 Fall
Bio333 Biochemistry 2 2019 Fall
Bio491 Special Projects 1 2019 Fall
Bio322 Research Topics in Molecular Biology 2019 Spring
Bio302 Biochemistry 2 2019 Spring
Bio700 Graduate Seminar 2019 Spring
Bio492 Special Projects 2 2019 Spring
Bio331 Techniques in Biological Research 2018 Fall
Bio333 Biochemistry Laboratory 2018 Fall
Bio570 Graduate Seminar 2018 Fall
Bio491 Special Projects 1 2018 Fall
Bio302 Biochemistry 2 2018 Spring
Bio593 Special Topics: Protein Biochemistry 2018 Spring
Bio700 Graduate Seminar 2018 Spring
Bio492 Special Projects 2 2018 Spring



last updated: 11/22/22