Resume - Necla BIRGÜL-IYISON


Asst. Prof. Dr. Necla Birgül-Iyison
Boğaziçi University
Molecular Biology and Genetics
Kuzey Park, 313
34342 Bebek/Istanbul
Turkey
+90 (212) 359 7284
birgul@boun.edu.tr
  download Dr. Birgül Iyison's CV
                (last updated: 08.11.2022)


Education

Start date Graduation date University Department (Program)
PhD Sep-97 Jan-01 University of Hamburg Institut für Zellbiochemie und klinische Neurobiologie
MSc Sep-94 Sep-97 University of Hamburg Institut für Allgemeine Botanik
BSc Sep-89 Sep-93 University of Hamburg Department of Biology

Academic Titles and Positions

Initial appointment at Boğaziçi University: Jan-02
First academic position at Boğaziçi University: Lecturer
Date of appointment as Assistant Professor at Boğaziçi University: 2004
Date Associate Professorship was granted by YÖK: Date
Date of promotion to Associate Professor at Boğaziçi University: Date

Experiences / Appointments (outside BU)

Employer Job Title Employment dates
University of Hamburg Postdoctorial fellow 2001 (3 month)
University of Cape Town Postdoctorial fellow 2001-2002

Research Interests

  • Molecular Biology
  • Signal transduction pathways
  • G-Protein Coupled Receptors (GPCRs)
  • Drug design
  • Molecular Dynamics and Simulation

Research Projects

Funding Institution Project Title Role Dates
Tübitak -19Z921 “Designing of pesticide molecules targeting allatostatin receptor” Principal Investigator 2019-2022
Tübitak–116S627 “Treatment of phenylketonuria in model organisms using CRISPR/Cas9 gene editing tool” Principal Investigator 2017- ongoing
Tübitak-213M730 Generation of multifunctional matrices by three-dimensional electrohydrodynamic and coaxial bioadhesive methods for skin regeneration Principal Investigator 2013-2017
Tübitak-113Z079 Identification, docking analysis and atomic force microscopy verification of binding pocket of allatostatin receptor in Cararusius morosus Principal Investigator 2014-2016
Tübitak-211T182 Examination of the transcriptional target of Wnt/B-catenin/TCF4 signaling pathway, C17orf45, on protein level Principal Investigator 2011-2012
Tübitak-108T183 Examination of the transcriptional target of Wnt/B-catenin/TCF4 signaling pathway, C17orf45, on protein level Principal Investigator 2011-2012
Tübitak-108T183 Identification of novel molecules which interact with Bri3 and Cnn3 by using yeast two hybrid system Principal Investigator 2008-2010
Tübitak-107S124 Prenatal expressions of hyperpolarization-activated cyclic-nucleotide-gated channel (HCN) genes in dysplastic hippocampi in rats Principal Investigator 2007-2008
Tübitak-106T153 Functional characterization of genes associated to cancer development through transcriptome analysis Researcher 2006-2008
BAP-19701 Cloning and purification of CARTp protein Principal Investigator 2022-2023
BAP-16464 Investigation of the mechanism of Cry toxins in Asian Mosquito Principal Investigator 2020-2021
BAP-14502 Characterisation of GPR139 and investigation its possible role in brain development Principal Investigator 2018-2019
BAP-13123 Verification of the RNA-Seq. data of Wnt/beta Catenin target BRI3 and MGAT Principal Investigator 2017-2018
BAP-12282 Generation and Analysis of the Neuropeptidome of Carausius morosus Principal Investigator 2017-2018
BAP- 9660 Analysis of the Wnt/beta Catenin target BRI3 and MGAT at transcriptomic level Principal Investigator 2015-2016
BAP-11480 Mutational screening of Phenylhydroxylase in Turkish Phenylketonuria patient Principal Investigator 2016-2017
BAP-8241 Effects of AlstR/AST combination in tumorigenesis Principal Investigator 2014-2015
BAP-6734 In Vivo analysis of the effects of novel wnt/beta-catenin targets on cancer development Principal Investigator 2011-2013
BAP-6657 Analysis of foxo transcription factor activities and GAD45 after lithium treatment of hepatocellular carcinoma cell lines Principal Investigator 2012-2013
BAP-5043 Analysis of the signal transduction pathway of Carausius morusus Principal Investigator 2010-2011
BAP-1876 Identification of novel molecules interacting with MGC 4057 by using yeast two hybrid system Principal Investigator 2008-2009
BAP-873 Identification of novel molecules interacting with Bri3 by using yeast two hybrid system Principal Investigator 2008-2009
BAP-764 Expressions analysis of hyperpolarization-activated Cyclic-Nucleotide-Gated Channel (HCN) genes in epileptic patients Principal Investigator 2007-2008
BAP-319 Molecular cloning of the full-length cDNA of the somatostatin-like G-Protein coupled receptor in Carausius morusus Principal Investigator 2003-2004
BAP-221 Molecular cloning of the full-length cDNA of a allatostatin receptor, which is a G-Protein coupled receptor in Carausius morusus Principal Investigator 2002-2003

Publications (overview)

Publications in refereed international journals
Index Publications
(from PhD)
Publications
(outside PhD)
Publications
(from BU Graduate Theses)
SCI-E/SSCI/AHCI 2 18 14
ESCI - - -
Scopus - - -
Other indexes - - -
Books
Books International Publishers: -
National Publishers: -
Book chapters International Publishers: 1
National Publishers: -
Edited Books International Publishers: -
National Publishers: -

Citations

Web of Science Google Scholar
h-index: 8 8
Number of citations w/o self citation: 352
Total number of citations: 371 526

Patents

Patent owner Title Number Application date Publication year Patent office
- - - - - -

Theses Supervised

MSc PhD Institution
Completed: - - -
Ongoing: - - -

Awards

Award Title Awarding Institution Award Year
- - -

Publications

Publications in refereed international journals

  • Ferdows Afghah, Necla Birgul Iyison, Ali Nadernezhad, Ahmet Midi, Ozlem Sen, Burcu Saner Okan, Mustafa Culha, and Bahattin Koc:“ 3D Fiber Reinforced Hydrogel Scaffolds by Melt Electrowriting and Gel Casting as a Hybrid Design for Wound Healing“ Advanced Healthcare Materials, 2022, 2102068, doi: 10.1002/adhm.202102068 Q1, IF: 11.92, SCIE

  • Serdar Durdagi, Muge Didem Orhan, Busecan Aksoydan, Seyma Calis, Berna Dogan, Kader Sahin, Aida Shahraki, Necla Birgül Iyison, and Timucin Avsar: „Screening of Clinically Approved and Investigation Drugs as Potential Inhibitors of SARS-CoV-2: A Combined in silico and in vitro Study“ Molecular Informatics, 2021 doi.org/10.1002/minf.202100062 Q1, IF: 4.05, SCIE

  • Aslan T, Yenenler-Kutlu A, Gerlevik U, Aktugülu Zeybek Ac, Kiykim E, Sezerman OU, Birgul Iyison N: "Identifying and elucidating the roles of Y198N and Y204F mutations in the PAH enzyme through molecular dynamic simulations." J Biomol Struct Dyn. 2021 May 10:1-12. doi: 10.1080/07391102.2021.1921619 Q1, IF: 4.15, SCIE

  • Shahraki, A., Isbilir, A., Dogan, B., Lohse, M.J., Durdagi, S., Birgul Iyison, N: "Structural and Functional Characterization of Allatostatin Receptor Type-C of Thaumetopoea pityocampa, a Potential Target for Next-Generation Pest Control Agents". J Chem Inf Model. 2021 Jan 21. doi: 10.1021/acs.jcim.0c00985 Q1, IF: 4.95, SCIE

  • Birgul Iyison, N., Shahraki, A., Kahveci, K., Duzgun, M.B., Gun, G: "Are Insect GPCRs Ideal Next-Generation Pesticides: Opportunities and Challenges". FEBS J. 2021 Jan 8. doi: 10.1111/febs.15708. Q1, IF: 5.54, SCIE

  • Birgul Iyison, N., Devlet Kilickap, B., Duan Sahbaz, B., Vardar, B., Guclu, B: "Distribution and mRNA expression of nAChRs in the rat S1 and M1 cortices after electrical stimulation of the basal forebrain". Turkish Neurosurgery, 2021 Jan 07. doi: 10.5137/1019-5149.JTN.31865-20.3 Q3, IF: 1.04, SCIE

  • Isbilir, A., Duan Sahbaz, B., Tuncgenc, G., Bünemann, M., Lohse, M.J., Birgul-Iyison, N:"Pharmacological Characterization of the Stick Insect Carausius morosus Allatostatin C Receptor with Its Endogenous Agonist". ACS Omega, 2020 Dec. DOI.10.1021/acsomega.0c03382 Q1, IF: 4.13, SCIE

  • Necla Birgul Iyison, Merve Gizem Sinmaz, Burcin Duan Sahbaz, Aida Shahraki, Busecan Aksoydan, Serdar Durdagi:“In silico characterization of adipokinetic hormone receptor and screening for pesticide candidates against stick insect, Carausius morosus“, Journal of Molecular Graphics and Modelling (2020) 107720, DOI.org/10.1016/j.jmgm.2020.107720 Q1, IF: 2.51, SCIE

  • Aida Shahraki, Yanying Yu, Zeynep Melis Gul, Chunguang Liang, Necla Birgul Iyison: “Whole Genome Sequencing of Thametopoea pityocampa Revealed Putative Pesticide Targets”, Genomics 112 (2020) 4203–4207, DOI.org/10.1016/j.ygeno.2020.07.017 Q1, IF: 5.73, SCIE

  • Akiva I. and N. Birgül Iyison: MGAT1 is a novel transcriptional target of Wnt/β catenin signaling pathway BMC Cancer 18:60 DOI.org/10.1186/s12885-017-3960-7, 2018 Q1, IF: 4.63, SCIE

  • Burcin Duan Sahbaz, Osman Ugur Sezerman, Hamdi Torun & Necla Birgül Iyison: Ligand binding pocket of a novel Allatostatin receptor type C of stick insect, Carausius morosus. Scientific Reports, 7:41266, DOI: 10.1038/srep41266, 2017, Q1, IF: 4.37, SCIE

  • Ayaz Najafov, Tuncay Şeker, İpek Even, Gerta Hoxhaj, Osman Selvi, Duygu Esen Özel, Ahmet Koman and Necla Birgül-İyison: Wnt/beta-Catenin pathway regulates transcription of actin-regulatory protein MENA, PLoS ONE, Volume 7, Issue 5, e37013, DOI:10.1371/journal.pone.0037013, 2012, Q , IF: 3.24, SCIE

  • Kavak E., Najafov A., Ozturk N., Seker T., Cavusoglu K., Aslan T., Duru A.D., Saygili T., Hoxhaj G., Hiz M.C., Ozer-Unal D., Birgul-Iyison N., Ozturk M., Koman A. „Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets“.Cellular Signalling, Vol. 22, pp. Q1, IF: 4.31, SCIE

  • Kreienkamp HJ, Larusson HJ, Witte I, Roeder T, Birgul N, Honck HH, Harder S, Ellinghausen G, Buck F, Richter D. “Functional annotation of two orphan G-protein-coupled receptors, Drostar1 and -2, from Drosophila melanogaster and their ligands by reverse pharmacology”. J Biol Chem. 2002 Oct 18;277(42):39937-43. Epub 2002 Aug 6. DOI:10.1074/jbc.M206931200 Q1, IF: 5.15, SCIE

  • Auerswald L, Birgul N, Gade G, Kreienkamp HJ, Richter D. “Structural, functional, and evolutionary characterization of novel members of the allatostatin receptor family from insects”. Biochem Biophys Res Commun. 2001 Apr13;282(4):904-9. DOI:10.1006/bbrc.2001.4659 Q1, IF: 3.19, SCIE

  • Birgul N, Weise C, Kreienkamp HJ, Richter D.“Reverse physiology in drosophila: identification of a novel allatostatin-like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin/galanin/opioid receptor family”. EMBOJ:18(21):5892–5900. DOI:10.1093/emboj/18.21.5892,1999 Q1, IF: 11.59, SCIE

Books, Book chapters, and Editorschips for international publishers

  • Duan Sahbaz B., Birgül Iyison N. “Ligands” Chapter: Neuropeptides as Ligands of GPCRs; In Tech Open Science, 2018

Publications in refereed national journals

  • Duan Sahbaz, B., Birgül İyison, N: Prediction and expression analysis of G protein-coupled receptors in the laboratory stick insect, Carausius morosus. Turkish Journal of Biology, 43, 77-88, DOI.10.3906/biy-1809-27, 2019, Q2, IF: 3.47, SCIE

  • İzzet Akiva, Necla Birgül Iyison:“Identification of IFITM3 and MGAT1 as novel interaction partners of BRI3 by Yeast Two-Hybrid Screening“, Turkish Journal of Biology, DOI.10.3906/biy-1805-47, 2018, Q2, IF: 3.47, SCIE

  • İ. Even, İ. AKİVA, N. Birgül Iyison:“In vivo RNAi mini-screen in Drosophila cancer model reveals novel potential Wnt targets in liver cancer“, Turkish Journal of Gastroenterology, DOI.10.5152/tjg.18241, 2018, Q3, IF: 1.55, SCIE

  • Isler C., Tanriverdi T , Kavak E., Sanus G.Z., Ulu M.O., Erkanlı G., Koman A., Birgül-Iyison N., Uzan M. “Prenatal Expressions of Hyperpolarization Cyclic-Nucleotide-Gated Channel (HCN) Genes in Dysplastic Hippocampi in Rats”, Türkish Neurosurgery 2008, Vol:18, No.4, 327-335. (PMID:19107678), Q3, IF: 1.03, SCIE

Books, Book chapters, and Editorschips for national publishers

  • -

Supervised Theses

Ongoing
  • Gökhan Gün:”Investigation of the mechanism of Cry toxins in Asian Mosquito”

  • Alize Yılmazlar: “Characterisation and functional analysis of the orphan G-protein coupled receptor GPR141”

  • Barbaros Düzgün: “Structural and functional analysis of the orphan G-protein coupled receptor GPR160”

  • Muhammed Fatih Karakaya: “Functional analysis of the orphan G-protein coupled receptor GPR25”

  • Kübra Kahveci: “Functional analysis of the allosteric pocket of Allatostatin receptor in T. pit”

Completed
  • Erşen Kavak: “Defining novel cancer genes, sage tags and co-regulated regions of the human genome evolving from the search and identification of novel Wnt/Tcf/beta-Catenin (PhD) targets”, 2009 (Co-advised)

  • Tuncay Şeker: “Proteomics based search for novel SIK2 substrates involved in Endoplasmic Reticulum homeostasis”, 2016 (PhD)

  • İzzet Akiva: “Characterization of novel Wnt/beta Catenin pathway targets”, 2016 (PhD)

  • Burçin Duan Şahbaz: “Neuropeptidome and GPCRome of Stick Insect: Specific structural and functional aspects of Allatostatin receptor”, 2017 (PhD)

  • Aida Shahraki: “Functional and Structural into novel insect G- protein coupled receptor Allatostatin Type C receptor of Pine processionary moth”, 2020 (PhD)

  • Tolga Aslan: “Characterization of GPR139 and investigating its possible role in brain development”, 2022 (PhD)

  • "Ayaz Najafov: Mena, Bri3 and Hsf2 as novel transcriptional targets of the
    Wnt/Beta-Catenin pathway; 2008
    Wnt/Beta-Catenin pathway; 2008 (MSc)"

  • "Tolga Aslan: Verification of putative novel Wnt/Beta-Catenin pathway targets
    using alternative effectors; 2009 (MSc)"

  • "Tuncay Şeker: Characterization of C17ORF45 as a novel target of Wnt/Beta-
    Catenin pathway; 2009 (MSc)"

  • "Izzet Akiva: Identification of novel proteins that interact with BRI3, a putative
    transcriptional target of the wnt/beta-Catenin signaling pathway; 2009 (MSc)"

  • Emine Dindar: Identification of protein partners of acidic calponin; 2010 (MSc)

  • "Ipek Even: Identification and in vivo analysis of putative Wnt target genes
    with effective roles in cancer; 2012 (MSc)"

  • "Burçin Duan: Identification and docking analysis of Allatostatin receptor in
    Carausisu morosus; 2012 (MSc)"

  • "Vahap Kapıkıran: C17ORF45 gene, does it or does it not translate a protein;
    2012 (MSc)"

  • "Esra Şekerci: How are foxo-transcription factors regulated after lithium
    induced cell cycle arrest in hepatocellular carcinoma cells; 2013 (MSc)"

  • "Ruçhan Karaman: Mammalian enabled (Mena): a possible regulator of YAP
    oncoprotein; 2014 (MSc)"

  • "Ali İşbilir: Pharmacological characterization of PICF-Allatostatin receptor in
    Carausius morosus; 2016 (MSc) "

  • "Merve Gizem Sınmaz: Characterization of Adipokinetik hormone receptor in
    stick insect, Carausius morosus; 2018 (MSc)"

  • Ayşe Nur Kayabaşı: Verification of novel Wnt/beta-Catenin Target, 2019 (MSc)

Conference Presentations

Conference contributions of the past 3 years
  • Burçin Duan Şahbaz ve Necla Birgül Iyison: Yeni Bir Allatostatin ReseptörününTanımlanması ve Ligand Bağlanma Cebinin Bulunması, 24. Ulusal Biyoloji Kongresi, Celal Bayer University Manisa/Izmir (10-14.09.2018)

  • Tolga Aslan ve Necla Birgül Iyison: Yeni bir PAH Varyantının Moleküler Modellemesi ve Moleküler Dinamik Simülasyonu, Erciyes Tıp Günleri Kayseri (7-10.03.2018)

  • İzzet Akiva ve Necla Birgül: “BRI3 is a novel Wnt/beta Catenin target” 1st International Multidisciplinary Cancer Research Congress” 18-22 September 2019, Diyarbakır

  • İzzet Akiva ve Necla Birgül: “BRI3 is a novel Wnt/beta Catenin target” 7th International Congress of the Molecular Biology Association of Turkey; 27-29 September 2019 Istanbul

  • Necla Birgul-Iyison: „Allatostatin receptor, potential target for next- generation pesticides“ 5th General ERNEST Meeting: Bridging Perspectives and Networking in Signal Transduction Research, Bari/Italy 4-6 October 2021

  • Kubra Kahveci, Serdar Durdaği, Necla Birgül: “Targeting Allatostatin Type-C receptor of Thaumetopoea pityocampa for novel agonists as next-generation pesticide” Agricultural, Biological & Life Sciences Conference 29-31 August 2022 Edirne, Turkey

Administrative Positions

Institution Faculty / Department Position Dates
Boğaziçi University FEF/MBG Vice Chair - MBG Department 2013 - 2017
Boğaziçi University BU Rectorate Vivarium Coordinator 2015- Ongoing
Boğaziçi University BU Rectorate Animal Ethics Committee member 2017- Ongoing
Istanbul Technical University ITU Rectorate Animal Ethics Committee member 2021- Ongoing

Courses of the past 5 years

Code Name Term Faculty Percentile Rank
Bio308 Seminar I 2021/2022-1 88.67
Bio48F Drug Design 2021/2022-1 70.44
Bio491 Special Project II 2021/2022-1 n.d
Bio308 Seminar I 2021/2022-2 n.d
Bio493 Signaling and Cancer 2021/2022-2 67.95
Bio492 Special Project II 2021/2022-2 n.d
Bio308 Seminar I 2020/2021-1 n.d
Bio407 Seminar II 2020/2021-1 n.d
Bio493 Signaling and Cancer 2020/2021-1 45.02
Bio 58F Drug Design 2020/2021-1 n.d
Bio308 Seminar I 2020/2021-1 n.d
Bio48F Drug Design 2019/2020-2 n.d
Bio492 Special Project II 2019/2020-2 n.d
Bio407 Seminar II 2019/2020-2 52.6
Bio355 Molecular Biology Lab. 2019/2020-I n.d.
Bio 58F Drug Design 2019/2020-1 82.35
Bio152 Introduction to modern Biology 2019/2018-2 n.d
Bio308 Seminar I 2019/2018-2 n.d
Bio492 Special Project II 2019/2018-2 n.d
Bio101 Cellular and Molecular Biology 2019/2018-1 n.d
Bio355 Molecular Biology Lab. 2019/2018-1 10.08 (Shared with TA’s)
Bio407 Seminar II 2019/2020-2 n.d
Bio491 Special Project I 2019/2018-1 n.d
Bio492 Special Project II 2017/2018-2 n.d
Bio308 Seminar I 2017/2018-2 n.d
Bio410 Cancer Biology 2017/2018-2 n.d
Bio111 Prelude to Molecular Biology 2017/2018-1 39.56 (Staff)
Bio355 Molecular Biology Lab. 2017/2018-1 28.16
Bio407 Seminar II 2017/2018-1 n.d
Bio407 Seminar II 2017/2018-1 n.d



last updated: 11/25/22