Asst. Prof. Dr. Fatih YANAR

Boğaziçi University
Molecular Biology and Genetics
Kuzey Park, 318
34342 Bebek - Istanbul
+90 (212) 359 7689

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    last updated: 29.07.2022
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My research interest focuses on two different topics: i) nanoparticle synthesis for drug delivery applications using flow reactors and ii) identification of genetic variations involved in the development of atherosclerosis.

Continuous-flow synthesis and characterization of nanoparticles for drug delivery applications

My research focuses on the production and characterization of nanoparticles that can be employed as diagnostic tools or nano-carriers for the controlled release of pharmaceutical actives. The synthesis of the nanoparticles is carried out in continuous flow reactors, which allows complete control over reaction conditions, such as sample volume, temperature, and mixing time. Thus, nanoparticles with the intended size can be produced without post-processing additional steps. Moreover, the employment of flow reactors for nanoparticle synthesis allows us to overcome limitations such as low production rates and high manufacturing costs. The aim of my research is continuous-flow production of novel drug delivery systems including liposomes and/or silver nanoparticles that can be used in controlled drug release applications.

Identification of genetic variations that are associated with coronary artery disease

Coronary artery disease (CAD) is one of the leading causes of death, especially in developing countries. It is characterized by reduced blood flow to the heart due to atherosclerosis, which is the formation of plaques made up of fatty substances in coronary arteries that eventually can cause serious complications such as heart attack or stroke. Studies on genes involved in the molecular mechanisms of atherosclerosis have shown that genetic variations play a significant role in the regulation of CAD risk factors such as inflammation and dyslipidemia. Identification of the genetic variations and molecular pathways is critical for the diagnosis and treatment of CAD. The aim of the research here is to investigate genetic variations such as single nucleotide polymorphisms that may contribute to the development of atherosclerosis and to identify potential biomarkers that can be used for early diagnosis of CAD.

Selected Publications

  • Yanar F, Mosayyebi A, Nastruzzi C, Carugo D, Zhang X
    Continuous-flow production of liposomes with a millireactor under varying fluidic conditions
    Pharmaceutics, 2020, 12(11):1001. doi: 10.3390/pharmaceutics12111001.

  • Demircan A, Coskunpinar E, Kanca D, Ozkara G, Yanar F, Kurnaz-Gomleksiz O, Bugra Z, Ozturk O, Yilmaz Aydogan H
    Role of SNPs of CPTIA and CROT genes in the carnitine-shuttle in coronary artery disease: a case-control study
    Turkish Journal of Biochemistry, 2019, 44(6): 822-30. doi: 10.1515/tjb-2018-0546.

  • Cristaldi DA, Yanar F, Mosayyebi A, García-Manrique P, Stulz E, Carugo D, Zhang X.
    Easy-to-perform and cost-effective fabrication of continuous-flow reactors and their application for nanomaterials synthesis
    New Biotechnology, 2018, 25;47:1-7. doi: 10.1016/j.nbt.2018.02.002.